Beauty with Brain is a story of rape, murder, revenge and love. Priya (Sonia Ojha) comes to the city to avenge the rape and murder of her sister Jyoti (Jyoti Mirke). With this in mind Priya confronts Manish (Mitesh Yadav) but he misguides her and tells her that three film producers were responsible for the crimes against her sister. However since all three of the producers are powerful influential people in their own right, Priya seeks help from Baba Ranawat (Imran Khan) an underworld don, to eliminate all three of the producers.
Ranawat helps Priya, however in the process she is told that though the producers raped her sister it was Manish who murdered her. If that wasn’t all Priya also finds out that Manish is in fact Ranawat’s brother. Will the don who has helped her once, assist her again in killing Manish? Will the don side her brother is what forms the rest of the film.