Missing On A Weekend is an investigating crime story based in Goa. Inspector Ali Ansari (Pavan Malhotra) a top cop from the CBI has been transferred to Goa to take charge of the current ugly undercover crime space which has troubled the tourism capital of India.
Ansari has now got a new case in the mid of all the chaos where one guy, Laksh (Karan Hariharan) has been found unconscious on Calangute beach. He is brutally hurt his head and lost substantial part of his memory. After the brief investigation, the police get to know his whereabouts in Goa. As the police team reaches the resort where Laksh and his six other friends from Delhi are staying, they find one of his friend dead in a room while the others are missing.
Now, Ansari is left with only one suspect cum victim cum survivor, Laksh, who hardly remembers anything that has happened. Will Ansari manage to find the others, will Laksh remember what happened on their vacation is what forms the rest of the story.