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MADGAON EXPRESS is the story of three friends in trouble. In 1998, Dhanush Sawant aka Dodo (Divyenndu), Pratik Garodia aka Pinku (Pratik Gandhi) and Ayush Gupta (Avinash Tiwary) of Mumbai are in Class 10 and they dream of going to Goa after their board examinations. Due to their parents' reluctance,... they are unable to do so. In 2003, they once again plan the trip after their graduation. Sadly, the car meets with the accident as soon as they begin their journey. The plan is yet again put on the backburner. A few years later, Pinku moves to Cape Town while Ayush migrates to New York. Both succeed in life and their pay package also increases. Meanwhile, Dodo is not able to have a steady job. He keeps in touch with Pinku and Ayush on social media and sees that they have become stinking rich. Hence, Dodo uses Photoshop to paint a false picture that he resides in a penthouse and is having the time of his life. In 2015, Pinku and Ayush decide to fly down to Mumbai. They inform Dodo about it and also tell him that they'll stay at his 'penthouse'! Dodo obviously gets tense and hence, he suggests that as soon as they land, the three of them should fulfil their plan of going to Goa. Pinku and Ayush agree. Since Dodo can't afford expensive flight tickets, he books three tickets in Madgaon Express under the pretext that they should travel like they would have, had they gone to the beach state in 2003! Pinku and Ayush hate the idea but give in. Sadly, for them, things go wrong even before they board the train and soon, they find themselves being confronted by dangerous criminals like Kanchan Kombdi (Chhaya Kadam) and Mendonza Bhai (Upendra Limaye). What happens next forms the rest of the film.
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