MADAME WEB is the story of a young woman who turns saviour for three teenage girls. In 1973, Constance Webb (Kerry Bishé) heads to the Peruvian Amazon in the eighth month of her pregnancy to research spiders that have healing properties. After a lot of effort, she finds the spider.... However, Ezekiel Sims (Tahar Rahim), her guard, snatches away the spider from her to get powers. He also shoots Constance before fleeing. Suddenly, members of the Las Arañas tribe arrive and they try to save Constance. In the process, she delivers a baby girl and then dies. 30 years later, Constance's daughter, Cassie Webb (Dakota Johnson) is working as a paramedic in New York City. One day, she realizes that she can see the future. Meanwhile, Ezekiel is also in New York and he gets visions of being killed by three masked women. He steals surveillance technology from a National Security Agency official and uses it to find them. He realizes that the women he saw in his dreams are actually teenage girls - Julia Cornwall (Sydney Sweeney), Anya Corazon (Isabela Merced) and Mattie Franklin (Celeste O'Connor). They are not related to each other and in a strange coincidence, they happen to be at the same place. Meanwhile, Cassie also sees the future wherein Ezekiel is trying to kill the girls. She bumps into the trio and escapes with them before Ezekiel can lay his hands on them. What happens next forms the rest of the film.
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