Life Mein Kabhie Kabhiee is the story of five friends, five lives, five years, one goal – happiness.

On their graduation day Manish (Aftab Shidasani), Rajeev (Dino Morea), Jai (Sameer Dattani), Monica (Nauheed Cyrusi) and Ishita (Anjori) get insanely drunk and have a bet that who out of them would be the happiest in life. They give themselves five years. At the end of five years Manish would decide who was the happiest. All of them have different ideas of happiness.

Rajeev thinks that to be the best in what you do is happiness,
Monica thinks fame is happiness
Jai thinks power is happiness
and
Ishita thinks money is what happiness is all about.

Life Mein Kabhie Kabhiee is the story of the journey of these five friends. What people do to achieve what they want? It is a journey of success and failure, triumphs and tribulations, hope and despair, happiness and sadness and of course the final question. Who will win the bet?